A material safety data sheet msds is a document containing information on the potential hazard. Levofloxacin hydrochloride is the hydrochloride salt of levofloxacin sc252953, a fluoroquinolone broad spectrum antibiotic with activity against grampositive and negative bacteria. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase bacterial topoisomerase ii, an enzyme required for dna replication, rna transcription, and repair of bacterial dna. Levaquin oral solution, 25 mgml is a multiuse selfpreserving aqueous solution of levofloxacin with ph ranging from 5. Levofloxacin rs and 5 gml of usp levofloxacin rerelative acceptance lated compound a rs in water from solution c and soretention criteria, lution d name time nmt % levofloxacin stock solution. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without warranty of any kind, expressed or implied. Safety and efficacy of levofloxacin versus ciprofloxacin.
Sds of sulfadimethoxine sodium salt, safety data sheets. Apr 01, 2019 levofloxacin is indicated for inhalational anthrax postexposure to reduce the incidence or progression of disease following exposure to aerosolized bacillus anthracis. Levaquin, levofloxacin systemic levofloxacin dosing. Dissolve usp levofloxacin rs in ndesmethyl levofloxacin a 0. The infusion time must be at least 30 minutes for 250 mg or 60 minutes for 500 mg levofloxacin see section 4. Safety and efficacy of additional levofloxacin in tuberculous meningitis. The material safety data sheet msds should accompany all shipments for reference in the event of spillage or accidental release. Page 3 of 5 7 handling and storage precautions for safe handling. It inhibits dna gyrase type ii topoisomerase and topoisomerase iv, thereby. The typical retention time of levofloxacin peak is about 7. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. The pharmacokinetics of levofloxacin lvfx, dr3355, the optically active component lisomer of ofloxacin, after a single oral administration of 100mg were studied in a total of 23 patients. Treatment of cns tuberculosis is based on the experience of. Levofloxacin 5 mgml solution for infusion summary of.
Levofloxacin investigated as a drug, mutagen, and reproductive effector. Onetenth of patients with extrapulmonary tuberculosis have central nervous system cns involvement which is the most severe form of tuberculosis resulting in high mortality and morbidity. Pdf evaluation of levofloxacin safety in broiler chickens. View download disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. The typical retention time of levofloxacin peak is about 6. A liquid is typically considered a nonconductive, static accumulator if its conductivity is below 100 psm 100x10e12 siemens per meter and is considered a semi conductive. Serious adverse effects fluoroquinolones, including levofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions e. Levofloxacin injection, for intravenous use, compare to levaquin. Levofloxacin hemihydrate, levaquin hydrate, tavanic hydrate, quixin hydrate, iquix hydrate. Only select registry of toxic effects of chemical substances rtecs data is presented here. Sds of levofloxacin, safety data sheets, cas 100986854. Levofloxacin hemihydrate sc211735 hazard alert code key. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease.
What is the most important information i should know about levaquin. The cdc recommends use as an alternative therapy only if standard parenteral cephalosporin therapy is not feasible. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase bacterial topoisomerase ii, an enzyme required for dna replication, rna transcription, and repair of. Sds of levofloxacin carboxylic acid, safety data sheets, cas. Fluoroquinolones, including levaquin, are associated with an increased risk of. Upper respiratory tract acute sinusitis mild to moderate due to streptococcus pneumoniae, haemophilus influenzae, or. Measurement and correlation for solubility of levofloxacin in. The effectiveness of levofloxacin is based on plasma concentrations achieved in humans, a surrogate endpoint reasonably likely to predict clinical benefit. Levofloxacin is a fluoroquinolone antibiotic indicated for susceptible infections of various parts of the body including airways, eyes, eyelids, prostate, sinus, lungs, urinary tract, skin, and kidneys.
Specific patterns of gyra mutations determine the resistance difference to ciprofloxacin and levofloxacin in klebsiella pneumoniae and escherichia coli. Levaquin levofloxacin tablets levaquin levofloxacin oral solution levaquin levofloxacin injection, for intravenous use levaquin injection, for intravenous use initial u. Some information presented and conclusions drawn herein are from. Levofloxacin is used for hospitalacquired pneumonia, communityacquired pneumonia, inflammation of the nasal passages, or worsening of longterm inflammation of the airways of the lungs also called, longterm bronchitis. The information on this msds was obtained from sources which we believe are reliable. We investigated the safety and efficacy of levofloxacin compared with ciprofloxacin for the treatment of chronic bacterial prostatitis in chinese patients.
Pharmacodynamics of levofloxacin and ciprofloxacin against. The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Transportation and shipping of this product is not restricted. However, the information is provided without any warranty, expressed or implied, regarding its correctness. Fluoroquinolones, including levaquin, are associated with an increased risk of tendinitis and tendon rupture in all ages. Please note, this oelade monograph also applies to levofloxacin hydrate cas rn 8199710. Use of levofloxacin levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial dna gyrase, halting dna replication. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only.
These recommendations apply to patients with creatinine clearance. Levofloxacin, sold under the trade names levaquin among others, is an antibiotic. For patients with creatinine clearance levofloxacin monograph for professionals. The usual dose of levofloxacin oral solution is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection and described in table 1. Levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis. Levofloxacin is active against grampositive and gramnegative bacteria. This was a multicenter, openlabel, randomized controlled noninferiority trial. See full prescribing information for complete boxed. Levaquin levofloxacin tablets levaquin levofloxacin oral. Sds are available online in the reference standards database, or upon request via the helpdesk the electronic versions of the european pharmacopoeia also include links. Clinically, gentamicin sulfate is used to treat severe.
Capitals indicate lifethreatening, underlines indicate most frequent. Measurement and correlation for solubility of levofloxacin in six solvents at temperatures from 288. Levofloxacin is a broadspectrum antibiotic used in pharmacokinetic, antibiotic resistance, and resistance prevention studies. Antibiotic against bacterial respiratory tract infections.
The appearance of levaquin oral solution may range from clear yellow to clear greenishyellow. Monitor prothrombin time, inr, watch for bleeding 7. Levofloxacin fda prescribing information, side effects and uses. Logarithmicphase cultures were exposed to the peak concentrations of levofloxacin or ciprofloxacin observed in human serum after 500 mg and 750 mg oral doses, human. Sandoz levofloxacin levofloxacin tablets is indicated for the treatment of adults with bacterial infections caused by susceptible strains of the designated microorganisms in the infections listed below. Identification of the substancemixture and of the companyundertaking product name. An invitro pharmacokinetic model was used to compare the pharmacodynamics of levofloxacin and ciprofloxacin against four penicillinsusceptible and four penicillinresistant streptococcus pneumoniae.
Details of the supplier of the safety data sheet 2. Levofloxacin is the active s isomer of the antibacterial agent ofloxacin sc219475 and is significantly more efficacious against bacteria than the r. Section 1 identification of the substancemixture and of. Show this safety data sheet to the doctor in attendance. These events may be severe, and generally occur following the administration of. Levofloxacin also displays anticancer activity, as when complexed with goldiii, it binds dna and inhibits cellular proliferation in several cancer cell lines.
Levofloxacin c18h20fn3o4 cid 149096 structure, chemical names, physical. The prevalence of tuberculosis in the world is 159100,000 population and onethird of these patients reside in india and china. Learn how to use levofloxacin, and its dosage, warnings, sideeffects, and more. If inhaled if breathed in, move person into fresh air. There are several ways to find pricing and availability for our products. Levofloxacin, hemihydrate, usp, levofloxacin, levofloxacin qacid, levofloxacin, hemihydrate, usp, levofloxacin, levofloxacin q. Read the medication guide that comes with levaquin before you start taking it and each time you get a refill. When the levofloxacin molecule interacts with ethanol, the. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. After eye contact rinse opened eye for several minutes under. You can contact any of our customer sales and service offices to receive a quote. Levofloxacin is a fluoroquinolone antibiotic that inhibits dna gyrase and topoisomerase iv. We ask that users who download significant portions of the database cite the.
Levaquin levofloxacin tablets levaquin levofloxacin oral solution levaquin levofloxacin injection levaquin levofloxacin in 5% dextrose injection to reduce the development of drugresistant bacteria and maintain the effectiveness of levaquin levofloxacin and other antibacterial drugs, levaquin should be used only to treat or prevent infections that are proven or strongly. One purpose of early clinical trials is to establish the appropriate dose of an antibiotic for phase 3 trials. Levaquin levofloxacin tablets levaquin levofloxacin. Fluoroquinolones, including levaquin, are associated with. First aid measures material safety data sheet material levofloxacin tablets 250 mg, 500 mg and 750 mg manufacturer lupin limited goa 403 722 india. Emergency overview gentamicin sulfate injection is a solution containing gentamicin sulfate, a complex aminoglycoside antibiotic substance with three components, sulfates of gentamicin c1, gentamicin c2 and gentamicin c1a. Development of a relationship between the ratio of drug exposure to organism minimum inhibitory concentration mic and therapeutic response early. Our msds database is an easy to use, do it yourself tool, and best of all.
If data for a hazard are not included in this document there is no known information at this time. Levaquin, a fluoroquinolone antibiotic, can cause serious side effects. Levaquin oral solution contains the following inactive ingredients. Buy levofloxacin hemihydrate cas 8199710, an antibiotic against gramnegative organisms, from santa cruz. Sandoz levofloxacin page 8 of 60 serious and sometimes fatal events, some due to hypersensitivity and some due to uncertain etiology, have rarely been reported in patients receiving therapy with quinolones, including levofloxacin. Extreme high moderate low section 1 chemical product and company identification product name levofloxacin hemihydrate statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Safety data sheets edqm european directorate for the.
Levofloxacin solution for infusion is only intended for slow intravenous infusion. Material safety data sheet levofloxacin hemihydrate sc211735 hazard alert code key. Levofloxacin should be kept in a tightly closed container, protected from light. Accidental release measures contain spill and collect, as appropriate.
Measurement and correlation for solubility of levofloxacin in six solvents at temperatures from. Levofloxacin hydrochloride cas 1773252 levofloxacin hydrochloride. By comparison, dermal levofloxacin concentrations in human subjects receiving 750 mg of levofloxacin. Levofloxacin oel fastrac with ade affygility solutions.
Fluoroquinolones, including levaquin, are associated with an. Download sds msds region certificate of analysis catalog. The information contained in this data sheet represents the best information currently available to us. By comparison, dermal levofloxacin concentrations in human subjects receiving 750 mg of levofloxacin averaged approximately 11. This product does not contain any chemicals known to the state of california to cause cancer, birth defects, or any other reproductive harm. Do not coadminister the intravenous formulation in the same iv line with a multivalent cation, e. It is used to treat a number of bacterial infections including acute bacterial sinusitis, pneumonia, h.
Some of these serious side effects can happen at the same time and could result in death. The present study was designed to investigate safety of levofloxacin 10 mgkg after repeated oral administration at 12 h interval for 14 days in broiler chicken 810 weeks old and weighing. Levofloxacin is a broadspectrum, thirdgeneration fluoroquinolone antibiotic and optically active lisomer of ofloxacin with antibacterial activity. Levofloxacin is contraindicated in children and growing adolescents see section 4. Antibacteriallevofloxacin reduced bacterial load compared with placebo by 4.
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